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Methods Chondrocytes were treated with H 2 O 2 for 1, 4, and 16 h followed by protein extraction and processing, including denaturation, alkylation, and trypsin digestion

Studies have shown that activating transcription factor 3 (ATF3) can mediate ferroptosis of osteoblasts in a high-glucose environment by inhibiting the activity of System Xc-, thereby inducing osteoporosis (27), and more studies have targeted GPX4 to inhibit ferroptosis, with the aim of treating osteoporosis (23, 24)

This can contribute to hair loss, especially when combined with nutrition deficiencies

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